- Secretory Carcinoma Arising in a Fibroadenoma: A Brief Case Report
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Sharon Lim, Min Keun Shim, Eun Yoon Cho, Soo Youn Cho
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J Pathol Transl Med. 2018;52(3):198-201. Published online October 4, 2017
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DOI: https://doi.org/10.4132/jptm.2017.08.01
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- Significance of Parafibromin Expression in Laryngeal Squamous Cell Carcinomas
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Inju Cho, Mija Lee, Sharon Lim, Ran Hong
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J Pathol Transl Med. 2016;50(4):264-269. Published online June 23, 2016
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DOI: https://doi.org/10.4132/jptm.2016.04.24
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 Abstract
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- Background
Parafibromin is a product of the tumor suppressor gene that has been studied as a potential indicator of tumor aggressiveness in the parathyroid, breast, colorectum, and stomach. However, the clinical significance and potential function of parafibromin expression in head and neck squamous cell carcinomas remain largely unknown. The aim of this study was to evaluate the expression of parafibromin in laryngeal squamous cell carcinoma (LSCC) and to verify its potential as a biomarker of tumor behavior.
Methods
Parafibromin expression was evaluated in 30 cases of LSCC using immunohistochemistry. The correlations between parafibromin expression and clinicopathologic parameters were investigated.
Results
Parafibromin expression was positive in 15 cases (50%) and negative in 15 cases (50%). Tumor size and T stage showed a statistically significant inverse relationship with parafibromin expression (p=.028 and p<.001, respectively). Parafibromin expression was not associated with age, sex, lymph node metastasis, tumor differentiation, or tumor location. There was no statistically significant relationship between parafibromin expression and progression-free survival in the patients (p>.05).
Conclusions
Our results indicate that the downregulation or loss of parafibromin expression can be employed as a novel marker of tumor progression or aggressiveness in LSCC.
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Citations
Citations to this article as recorded by  - Advances in the application of label‐free quantitative proteomics techniques in malignancy research
Xiao Meng, Dong Liu, Yan Guan
Biomedical Chromatography.2023;[Epub] CrossRef - The roles of the tumor suppressor parafibromin in cancer
Hua-chuan Zheng, Hang Xue, Cong-yu Zhang
Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef - The clinicopathological and prognostic significances of CDC73 expression in cancers: a bioinformatics analysis
Hua-Chuan Zheng, Bao-Cheng Gong, Shuang Zhao
Oncotarget.2017; 8(56): 95270. CrossRef
- Digital Papillary Carcinoma
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Sharon Lim, Inju Cho, Mi Ja Lee
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Korean J Pathol. 2014;48(6):438-441. Published online December 31, 2014
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DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.6.438
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8,035
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Citations
Citations to this article as recorded by - Digital papillary adenocarcinoma: A case report
Betty A. Kasimo, Vivian Akello, James J. Yahaya
Clinical Case Reports.2021;[Epub] CrossRef - A rare case of a digital papillary carcinoma of the hand with secondary conservative management
Rabeet Khan, Renu Irri, Effie Katsarma
Journal of Surgical Case Reports.2020;[Epub] CrossRef
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